Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer
نویسندگان
چکیده
منابع مشابه
Cell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancer
The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor survival has been of notable interest. The present study aimed to assess the poten...
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Glucose regulated protein 78 (GRP78) is predominantly located in the endoplasmic reticulum as a molecular chaperone. It has also been found on the membranes of some cancer cells, acting as a receptor for a wide variety of ligands. However, its presence on colorectal cancer (CRC) cell surface and its role in CRC metastatic progression remain elusive. Here we reported that GRP78 was predominantly...
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1MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, UK 2Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK 3Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA 4Department of Pharmacology and Toxicology, Michigan State University...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2020
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2020.10.055